Definition:
PUVA means psoralen ultra violet ray. It is the irradiation with only UVA which
may be performed with special fluorescent tubes. This form of ultra violet ray
is usually given two hours after the patient has taken a photoactive drug 8
Methoxy psoralen.
Mechanism:
Psoralen is a drug which makes the skin and the lens of eyes temporarily
sensitive to UVA. The drug alone is inactive in the skin, but it becomes
activated in the presence of UVA and binds to the DNA thiamine bases.
Dosage:
Dosage depends upon the patient skin type. Dosage on a PUVA regimen is measured
using J/Cm2. The dose may increased by 0.5 J/Cm2 to 2 J/cm2
Indication:
PUVA has been shown to be very successful in controlling the following
diseases;
1. Psoriasis
2. Atopic
eczema
3. Vitiligo
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