Gentamicin: It
is a member of aminoglycoside isolated from Micromonospora purpurea.It is
effective against both gm +ve & gm –ve organism.
Mechanism of action
Gentamicin is a bactericidal antibiotic that works by
irreversibly binding the 30S subunit of the bacterial ribosome, interrupting
protein synthesis. This mechanism of action is similar to other Aminoglycosides
Indications:
1) Infection with pseudomonas,proteus,
enterobacter, klebsiella etc.
2) Gentamicin + Penicillin G→in
subacute endocarditis by S.Viridance & enterococci.
3) Gentamicin + Nafcillin→in staph
endocarditis.
4) Meningitis caused by gm(-ve)
bacteria.
5) Serious gm(-)ve septicemia.
6) Abdominal & pelvic sepsis.
7) In case of surgical procedure.
Adverse
effects:
1) Nephrotoxicity.
2) Ototxicity.
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