Name the spore bearing organism:
[A]Grame positive bacilli:
a)
Clostridium tetani.
b)
Clostridium botulinum.
c)
Baciflus subtilis.
d)
Bacillus anthracis.
[B]Gram negative cocci:Sporosarcina.
[C]Gram negative coccobacilli:Coxiella burnetii.
Spore bearing bacilli→Disease
a)
Bacillus
anthracis→Anthrax.
b)
Bacillus cereus→Food
poisoning.
c)
Clostridium
tetanus→Tetanus.
d)
Clostridium botulinum→Botulism.
Pathogenesis of
anthrax in human:
Bacillus anthracis invades the host tissue
↓
Production of anthrax toxin
↓ Anthrax
toxin has 3 components
-Protective antigen.
↓ -Edema
factor.
-Lethal factor.
Protective antigen form spores in the human cell
membrane.
↓
Clavage of phosphokinase(that activates mitoge
activated protein kinase MAPK signal transduction pathway )By lethal factor.
↓
Inhabits pathway that control the growth of human cell
↓
Inhibition of cell growth.
↓
Anthrax
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