Definition: Necrosis refers to a spectrum of morphologic
changes that follow cell death in living tissue, largely resulting from the
progressive degradative action of enzymes on the lethally injured cell.
Classification/types of
nacrosis with example:
[A] Basic types:
1. Coagulative
necrosis: e.g- ischemic necrosis of heart (myocardial infarction) , kidney,
liver, adrenal gland and other solid organs.
2. Liquefactive/colliquative
necrosis: e.g.- Abscess, boil and ischemic necrosis of brain tissue.
[B]
Special types:
1. Caseous
necrosis: e.g-granuloma of tuberculosis.
2. Fat
necrosis:
a) Enzymatic
fat necrosis: e.g- enzymatic fat necrosis of pancreas and omental tissue.
b) Traumatic
fat necrosis: e.g- traumatic fat necrosis of breast.
3. Gangrenous
necrosis: e.g- any necrosis with superadded putrefaction.
4. Fibrinoid
necrosis: e.g- Acute rheumatic fever, rheumatoid arthritis, systemic lupus
erythematosus (SLE)
5. Necrosis
of muscle: e.g- Zenker’s degeneration.
6. Osteonecrosis:
Necrosis of bone an affect the medullary bone with its medullary avity and
trabecular bone or affect both medullary and cortical bone.
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