Ketoconazole
Ketoconazole:
They are imidazoles. Less selective for fangal cytochorome P450 enzymes. More
side effects. Contraindicated in pregnancy(Present in breast milk)
Indications
of Ketokonazole:
1.Systemic
fungal infection(because it is absorped from gut) & widely distributed.
2.Superficial
mycoses.(Topical use).
3.Advance
prostatic cancer(because it impairs testosterone synthesis)
4.Hyper-adrenal
corticocism(because it impairs testosterone synthesis)
Advers
effects of Ketokonazole:
1.↓Libido in man
2.Gynacomastia.
3.Liver damage.
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