Name the
exotoxin and endotoxin producing bacteria:
[A] Endotoxin producing bacteria:
·
E.coli.
·
Klebsiella.
·
Salmonella.
·
Shigella.
·
Proteus.
·
Brucella.
·
Neisseria.
[B] Exotoxin producing bacteria:
a)
Gram(+ ve)bacteria:
·
Clostridium tetani.
·
Clostridium botulinum.
·
Clostridium defficile.
·
Clostridium perfingens.
·
Bacillus anthracis.
b)
Gram(- ve)bacteria:
·
Vibriocholera.
·
Pseudom Aeromonas.
·
Bordetella parteusis.
·
Aeromonas.
Difference between exotoxin & endotoxin:
Exotoxin
|
Endotoxin
|
(1)Excreted by living
cells.
|
(1)Integral part of the
cell wall.Relased on bacterial disintegration.
|
(2)Produced by Gram
positive and Gram negative bacteria.
|
(2)Formed only by Gram
negative bacteria.
|
(3)Polypeptides.
|
(3)Lipopolysaccharides
lipid A is toxic.
|
(4)Usually binds to
specific receptors on cells.
|
(4)No specific receptors.
|
(5)Highly toxic.Fatal in
small doses.
|
(5)Moderately toxic.Fatal
in large doses.
|
(6)Relatively heat
labile.Toxicity destroyed over 60 c.
|
(6)Relatively heat
stable.Toxicity is not destroyed above 60 c for hours.
|
(7)Highly
antigenic.Stimulates formation of antitoxin.Antitoxin neutralizes the toxin.
|
(7)Weakly
antigenic.Antibodies are protective but to a lesser extent than antitoxin.
|
(8)May be converted to
toxoid by formalin.
|
(8)Not coverted to toxoid.
|
(9)Usually under cotrol of
extra chromosomal genes.
|
(9)Under control of
chromoosmal genes.
|
(10)Usually do not produce
fever.
|
(10)Usually produce fever.
|
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