Q: What are the enzymes of clinical importance?Give their normal values with clinical significance

Q: What are the enzymes of clinical importance?Give their normal values with clinical significance

Ans: Enzyme/Normal values/Clinical importance:

Enzyme
Normal value
Clinical importance
Present
a.Aspartate transaminase(AST)
10-35 IU/L
Increased in
*MI.
*Non viral hepatitis.
*Cirrhosis.
Heart & Liver
b.Alanine aminotransparase(ALT)
10-40 IU/L
Increased in
*Liver damage.
*MI.
*Muscular dystrophy.
*Sever muscle injury.
Heart & Liver
c.Lactate dehydrogenase(LDH)
230-460 IU/L
Incerased in
*MI.
*Viral hepatitis.
*Megaloblastic anaemia.
*Leukaemia.
*Malignancy.
*Muscular dystrophy.
*Renal disease.
Heart,Liver,Muscle,
RBC
d.Acid Phosphatas(ACP)
0.5-4 IU/L
Increased in
*Prostate carcinoma.
*Paget’s disease.
*Hyper parathyroidism.
Prostate
e.Creatinine Phosohokinase
Male:30-200
Female:30-150
Increased in
*MI(Markedly)
*After exercise.
*Muscle injury.
Muscle including cardiac muscle.
f.δ-glutamul Transferase
Mle:10-55
Female:5-35
disease of hepatobilary system
Liver

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