Q: What are the
enzymes of clinical importance?Give their normal values with clinical
significance
Ans: Enzyme/Normal
values/Clinical importance:
Enzyme
|
Normal value
|
Clinical importance
|
Present
|
a.Aspartate
transaminase(AST)
|
10-35 IU/L
|
Increased in
*MI.
*Non viral hepatitis.
*Cirrhosis.
|
Heart & Liver
|
b.Alanine
aminotransparase(ALT)
|
10-40 IU/L
|
Increased in
*Liver damage.
*MI.
*Muscular dystrophy.
*Sever muscle injury.
|
Heart & Liver
|
c.Lactate
dehydrogenase(LDH)
|
230-460 IU/L
|
Incerased in
*MI.
*Viral hepatitis.
*Megaloblastic anaemia.
*Leukaemia.
*Malignancy.
*Muscular dystrophy.
*Renal disease.
|
Heart,Liver,Muscle,
RBC
|
d.Acid Phosphatas(ACP)
|
0.5-4 IU/L
|
Increased in
*Prostate carcinoma.
*Paget’s disease.
*Hyper parathyroidism.
|
Prostate
|
e.Creatinine
Phosohokinase
|
Male:30-200
Female:30-150
|
Increased in
*MI(Markedly)
*After exercise.
*Muscle injury.
|
Muscle including cardiac
muscle.
|
f.δ-glutamul Transferase
|
Mle:10-55
Female:5-35
|
disease of hepatobilary
system
|
Liver
|
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