Definition: Drugs or derives which are used to
avoid unwanted contraception are called contraceptives.
Characteristics of ideal contraceptives:
1)
Highly effective.
2)
Safe.
3)
Effect should be quick in onset.
4)
Available.
5)
Acceptable.
6)
Inexpensive.
7)
Comletely & totaly,quickly reversible.
Composition of oral contraceptive pill:
[A]OCP:
1)
Synthetic oestrogen→Ethenyl estradiol or Mestranol(It is a
prodrug.It is converted to EE in the liver.It may produce hepatoma)
2)
Progesterone→Levonogestril,Desogestril
[B]POP:Progesteron only pill(Minipill)
Adverse effects of oral
contraceptive pills:
[A]Major:
1.Cardiovascular
effects
|
OCP causes increased risk of
a)
Thromboembolism.
b)
Coronary artery disease.
c)
Atherosclerosis.
d)
HTN.
|
2.Metabolic effects
|
↓HDL.
↑Cholesterol
↑LDL
|
3.Hepatic effects
|
Ca of liver.Chloestatic jandice.
|
4.Psychological effects
|
Depression-due to lack of vit
|
5.Supress lactation
|
|
6.Neoplasia
|
Fibro-adenoma of breast
Fibroid uterus
|
[B]Minor:
1)
Nausea,Vomiting.
2)
Headache.
3)
Leg crump.
4)
Wt gain.
5)
Break through.
6)
Hypomenorrhoea.
7)
Amenorrhoea.
8)
Menorrhagea.
Contraindications of OCP:
Absolute
|
Relative
|
Special prcaution
|
1.History of CVS disease.
2.Liver disease(ch Hepatitis)
3.Breast cancer
|
1.HTN.
2.Obesity.
3.Migraine.
4.Endogenous smoking.
5.Heavy smoking.
|
1.DM.
2.Collagen disease.
3.Osteosclerosis.
4.Sever varicose Veins.
5.Sickle cell disease.
6.Surgical operation.
7.History of depression.
8.Age over 35 years.
|
Advantages of OCP:
1) Disease risk of:
·
Benign breast disease.
·
Fibroadenoma of breast.
·
Endometriosis.
·
PID.
·
Iron deficiency anaemia.
2)
↓risk of ectopic pregnancy.
3)
Prevention of dysmenorrhoea.
4)
Relief of premenstrual tension.
Therapeutic indication of oral pill:
1)
Menstrual irregularity (3month)
2)
Endometriosis-most effective treatment is pregnancy.
Indication of Progesterone:
1)
Disorder of menstruation & ovulation:
·
Amenorrhoea.
·
DUB.
·
Spasmodic dysmenorrhoea.
·
Premenstrual syndrome.
2)
Conceptioin & pregnency:
·
Contraception.
·
Infertility
3)
Endometriosis.
4)
Hormone replacement therapy.
5)
Pelvic cancer.
6)
Breast condition.
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